We found that DP IEL numbers in mice varied in different vivaria, correlating with the presence of Lactobacillus reuteri. DP IELs are absent in germ-free mice, which suggests that their differentiation depends on microbial factors. reuteri, together with a tryptophan-rich diet, can reprogram intraepithelial CD4+ T cells into immunoregulatory T cells.ĪB - The small intestine contains CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4+ T cells through down-regulation of the transcription factor Thpok and have regulatory functions.
reuteri did not shape the DP-IEL-TCR (TCR, T cell receptor) repertoire but generated indole derivatives of tryptophan that activated the aryl-hydrocarbon receptor in CD4+ T cells, allowing Thpok down-regulation and differentiation into DP IELs.
This species induced DP IELs in germ-free mice and conventionally-raised mice lacking these cells. N2 - The small intestine contains CD4+CD8αα+ double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4+ T cells through down-regulation of the transcription factor Thpok and have regulatory functions. T1 - Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells
0 kommentar(er)
